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Publications, guides, and technical resources
Simplified rAAV Lysate Purification for Complex Analytics of Upstream Samples
Explore the CIM® SO3 0.2 mL Monolithic 96-well Plate's role in optimizing rAAV upstream production. Learn how Sartorius BIA Separations and BridgeBio Gene Therapy's approach expedites AAV analytics and reduces process development costs, achieving high capsid recovery and offering a cost-effective alternative to traditional purification methods.
PublicationspH Denaturation of dsRNA: A Novel Approach to mRNA Purification
A novel method improves mRNA purity by targeting dsRNA hydrogen bonds, enhancing chromatographic differentiation and cellular potency.
PublicationsViral Clearance in a Downstream AAV Process: Case Study Using a Model Virus Panel and a Noninfectious Surrogate
Michael Winkler, Mikhail Goldfarb, Shaojie Weng, Jeff Smith, Susan Wexelblat, John Li, Alejandro Becerra, Sandra Bezemer, Kevin Sleijpen, Aleš Štrancar, Sara Primec, Romina Zabar, April Schubert, Akunna Iheanacho, and David...
Method GuidesQuick Guide for Purification of mRNA With CIM® Octa Oligo dT Columns
This method guide describes the use of CIM® Octa Oligo dT columns for the purification of mRNA. The document is designed to assist in use of the columns for automated...
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Insights and updates from BIA Separations
A Guide to Monolithic Column Channel Sizes
A guide to choosing the right channel size of monoliths for biomolecules: pDNA, mRNA, AAV, LVV, bacteriophages, LNP, proteins, and more
Read more →What’s Holding Back mRNA-LNP Therapeutics?
Solving challenges in the areas of purity, consistency, and monitoring technologies is crucial for the development of mRNA-LNP therapeutics.
Read more →How Acidic Denaturation Facilitates dsRNA Removal
How to remove double stranded RNA for safer mRNA therapeutics, without special equipment and preserving the target molecule
Read more →The Next Generation of Chromatography: Moving From Classic HPLC to Advanced Platforms
Advanced chromatography platforms enhance process development with integrated solutions beyond traditional HPLC systems.
Read more →